It's completely valid to come to the conclusion that someone else can't be a worthy audience, conversation partner or otherwise interact with you. You can quietly say to yourself, "this guy is a stiff, I'm never going to be able to please him." But the minute you throw back instructions designed to 'cure' the other person, I fear you're going to get precisely the opposite of what you were hoping for.
(Generally speaking, the word "oh" is so neutral, it's a helpful go to pause while you wait for things to calm down.)
The one that gets me is "Get over it."