I just submitted this to Apple as rdar://problem/7031368:

I have been using Safari 4 for weeks and am convinced the new location of the refresh button is plain wrong. Conceptually I think of it as something that should be grouped with the other frequently used buttons on the left side of the toolbar. More importantly (and measurably), my mouse is *much* more often near the top left of the window than where the refresh button currently is:

• Most web pages put a Home link in the upper left.
• The Back and Forward buttons are on the upper left, as is the window's close button.
• If I'm looking at multiple tabs and I want to close or drag the tab I'm looking at, most often it will be one of the first two tabs.

Over and over again I start moving the mouse to the upper left, then remember where the refresh button is and have to change course, which is extremely annoying. Please at least provide an option to put a refresh button in the traditional location by customizing the toolbar.

It's odd that this bugs me so much, because I tend to strongly prefer keyboard shortcuts to mousing, and Command-R is a very easy shortcut to type. I'm not sure why I've been using the mouse so much to refresh. As for why I'm refreshing so much in the first place, I think I do it mostly on Facebook, though I also do it with YouTube pages that need to get reloaded to get unstuck, and with any page where I've been following comments.

This workaround occurred to me today: I added a link to the left end of the bookmarks bar with the name "Reload" and the URL javascript:window.location.reload(). Now there's a little less annoyance in my day.